AIDS vaccine offers hope in early trial

Jul 10, 2018, 04:57
AIDS vaccine offers hope in early trial

A new experimental vaccine to fight off HIV-1 has sparked a new hope to protect those who are having HIV, one of the most widespread virus and the leading causes of death of many people globally.

"The challenges in the development of an HIV vaccine are unprecedented, and the ability to induce HIV-specific immune responses does not necessarily indicate that a vaccine will protect humans from HIV infection", he explains. Moreover, the vaccine candidate protected against infection with an HIV-like virus in monkeys.

An accompanying editorial by George N. Pavlakis, MD, and Barbara K. Felber, PhD, both of the National Cancer Institute in Frederick, Maryland, discussed this approach, stating that it "defines an additional path for exploring the development of an effective HIV vaccine".

With 37 million people living with HIV/AIDS, and an estimated 1.8 million new cases each year, a preventative vaccine is urgently needed to curb this worldwide pandemic.

The study was conducted in 2015-2016, and in July 2017, scientists told the world about the results. Till date, this is the first out of five HIV vaccine concepts to have showed a positive response in nearly around 40 years of the HIV virus causing havoc among humans.

The vaccine containing "mosaic" HIV Env/Gag/Pol antigens was created from many HIV strains, delivered using a non-replicating common-cold virus (Ad26).

The Ad26/Ad26 plus gp140 vaccine candidate induced the greatest immune responses in humans and also provided the best protection in monkeys, resulting in complete protection against infection of SHIV, a virus similar to HIV that infects monkeys, in two-thirds of the vaccinated animals.

The new vaccine proved to be protective in monkeys, and while antibodies against HIV were generated in humans, it is unclear whether the vaccine will protect against infection. The human trial participants came from 12 clinics in South Africa, east Africa, Thailand and the United States.

"Based on these data, the mosaic Ad26/Env HIV-1 vaccine has been advanced into a phase 2b clinical efficacy study to determine whether this vaccine will prevent HIV infection in humans in southern Africa", said Barouch.

While these results are not ideal, they "represent an important milestone", Harvard professor, Dan Barouch, said.

About nine years ago, another HIV vaccine, RV144, also showed positive results in initial experiments carried out on 16,000 volunteers in Thailand. We thank the International AIDS Vaccine Initiative (IAVI) and the generous support of USAID and other donors; a full list of IAVI donors is available online.

Some of the volunteers reported some side effects but the researchers said they were tolerable.

Dr Brady added that in the meantime there were already tools that were effective for preventing the disease from spreading, such as contraception and treatments for HIV-positive people that prevent them from passing on the virus.

"Despite all the advances we have had with HIV, we need a vaccine". The mosaic is one of five vaccines to ever make it this far in the testing stages, but none of the previous vaccines were successful enough to make it to the next round of testing. "But the data is promising and we are happy to report the immune response".

YOU MIGHT ALSO LIKE
  • Samsung’s biggest factory will be inaugurated in India today

    Samsung’s biggest factory will be inaugurated in India today

    The mobile phone plant can produce almost 12 crore mobile phones every year, and will create 15,000 job opportunities. India is a country with a population of 1.3 billion people, and yet there are only 425 million smartphone users.
    LeBron James Has Yet To Meet With Lakers Coach Luke Walton

    LeBron James Has Yet To Meet With Lakers Coach Luke Walton

    With Randle's departure, the Lakers will have no players left on their roster who played with Bryant in his final game in 2016. It just got a whole lot more expensive to be a Lakers fan. "So my expectations are the exact same thing".
    Cult leader executed for Japan sarin attacks still a mystery

    Cult leader executed for Japan sarin attacks still a mystery

    Japan's Justice Ministry later confirmed reports that six followers of the cult had been executed along with the leader. A 2015 government survey found that 80.3 percent of people supported the death penalty.
  • USA  secretary of state unconcerned over 'gangster-like' N Korea talks

    USA secretary of state unconcerned over 'gangster-like' N Korea talks

    I expect that the DPRK is ready to do the same, ' Pompeo said, using the initials for North Korea's official name. Even so, the U.S. envoy yesterday insisted again that he thought the talks were "in good faith and productive".
    Syria rebels say close to deal with Russian Federation  on south

    Syria rebels say close to deal with Russian Federation on south

    All areas along the Syrian-Jordanian border will be under the direct control of Syrian government forces, SANA reported . He said he was angry at Jordan for keeping its border closed "and watching us dying".
    Can England go one step further? Lawro's World Cup predictions

    Can England go one step further? Lawro's World Cup predictions

    England will play against Sweden while hosts Russian Federation square off against Croatia on July 7 at 7pm and 11pm respectively. Lawro picked the victor in six of the eight last-16 ties, and correctly predicted the outcome of 22 of the 48 group games.
  • Kylie Jenner Removes Lip Fillers, Shows Off Her Smaller Lips

    Kylie Jenner Removes Lip Fillers, Shows Off Her Smaller Lips

    For many years, she denied touching the stuff at all - despite the fact her lips were expanding at an exponential rate. The 20-year-old star became insecure about her lips after a comment from her teenage crush.
    Thai Cave Rescue Operation Suspended After 4 More Boys Freed

    Thai Cave Rescue Operation Suspended After 4 More Boys Freed

    During this process, rescuers need to hold the boys' oxygen tanks in front of them and swim pencil-like through submerged holes. However, even after their ordeal is over, the children could still suffer post traumatic stress disorder, experts have warned.
    Croatia sack assistant ahead of World Cup semi-final with England

    Croatia sack assistant ahead of World Cup semi-final with England

    Petersburg, Sochi, Kazan, Saransk, Kaliningrad, Volgograd, Rostov-on-Don, Nizhny Novgorod, Yekaterinburg and Samara. The country selected 11 host cities to be the venues for the matches of the 2018 World Cup and they are Moscow, St.
  • India Delhi bus gang rapists lose death row plea

    India Delhi bus gang rapists lose death row plea

    Singh was dumped on the streets 45 minutes later with horrific internal injuries, and died 13 days later in a Singapore hospital. The woman was raped on the intervening night of December 16-17, 2012 in a running bus in south Delhi by six persons.
    Belgium beats Brazil 2-1 in quarterfinals

    Belgium beats Brazil 2-1 in quarterfinals

    Lukaku dropped into midfield and fed de Bruyne, who smashed home an unstoppable strike from the edge of the penalty area. They paid an immediate price when Fernandinho nodded Eden Hazard's corner into his own net unpressured after 13 minutes.
    Iran set for disappointment over nuclear deal talks

    Iran set for disappointment over nuclear deal talks

    Washington has since told countries they must stop buying the OPEC producer's oil from November 4 or face financial consequences. They are trying to present this as a response to an Iranian "threat" to close the area.
popular