The latest bombing claimed the lives of Additional Inspector General Hamid Shakeel, his driver and another police officer, while three others were seriously wounded.
The suicide bomber targeted a vehicle carrying Deputy Inspector General Hamid Shakeel, who was leaving his residence, police said.
Four other policemen were also wounded in the bombing, the officer said, adding that Shakil was wounded in the blast but died en route to hospital. Reports confirmed that DIG's auto was badly damaged in the explosion.
Hours after the attack, the Pakistani Taliban, known as Tehrik-e-Taliban Pakistan, claimed responsibility.
Police, rescue teams and security forces rushed to the site and shifted the injured to the Civil Hospital and the Combined Military Hospital in the city where the officer and two other policemen succumbed to their injuries during treatment.
The area has been cordoned off and a search operation has been launched in the surrounding areas.
Meanwhile, Chief Minister Balochistan Nawab Sanaullah Khan Zehri has strongly condemned the bomb attack on Police vehicle.
At least six police commandos and a civilian were killed last month when an explosives-laden vehicle rammed into a security force's convoy on the Quetta-Sibi Highway.
Suicide attacks have accelerated in the southwestern region of Pakistan, endangering a planned economic corridor with China.
In June this year, 14 people, including seven policemen, were killed and 21 others were injured in a suicide auto bombing on Gulistan Road in Balochistan.
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