October Proclaimed Breast Cancer Awareness Month by County Commissioners

Oct 25, 2017, 00:21
October Proclaimed Breast Cancer Awareness Month by County Commissioners

The finding is expected to allow researchers to develop a simple blood test within five years to be used in conjunction with a breast screening to help pinpoint specific genes associated with breast cancer.

Six months ago, something came up wrong in a mammogram for our own Stacy Lyn.

Cambridge University and partners in a five-star global research alliance have identified seventy-two new genetic variants that contribute to the risk of developing breast cancer.

For one in five women, the family history written into their genes increases their risk of being diagnosed by nearly a third. Doctors hope the new information released from a study by an worldwide team of 550 researchers help them understand the genetic role of the disease.

Researchers from Quebec city are now hoping to obtain the necessary financing to assess the feasibility and acceptability of this new method of assessing the risk of breast cancer. The researchers found that non-cancerous breast tissue had more of a certain type of bacteria, and the cancerous tissue had other types that were elevated.

"So, if a woman is a carrier of five variations, each of which increases the risk of breast cancer of 20 %, this risk becomes substantial since it is 2.5 times bigger than (1,25)", says Jacques Simard Centre de recherche du CHU de Québec-Université Laval, who is one of four principal investigators of the study that is the subject of two publications in Nature and Nature Genetics. The World Health Organisation suggests breast cancer as one of the leading causes of mortality in women, especially in developing countries where most cases are detected in the later stages.

United States co-author Professor Peter Kraft, from the Harvard TH Chan School of Public Health, said the findings revealed a wealth of new information about the genetic mechanisms underlying the disease. "There's been a lot of research trying to figure out what that something else is".

Significant changes in serum levels of estradiol and sex hormone-binding globulin and other yet unidentified mechanisms are responsible for the association between increased activity level and decreased risk for breast cancer.

However, not all cancer cells carry this receptor - these are known as oestrogen-receptor negative. "It is estimated that worldwide over 508 000 women died in 2011 due to breast cancer", WHO.

Lifestyle changes such as diet, body weight, exercise and alcohol consumption are some of the modifiable risk factors for this disease.

A further seven genes were identified specifically in association with breast cancers that lacked oestrogen receptors, which don't tend to respond to hormone based therapies.

The discovery of these 72 genetic variation also provides information for researchers " on the biology behind the development of cancer of the breast and on the different sub-types of breast cancer", which should enable it to find "new therapeutic targets", says Mr. Simard.

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