Julen Lopetegui's side now boast a goal difference advantage of 17 over the Italians who need just a point from their game against Macedonia to guarantee a top-two finish and a place in the play-offs.
Wales are in a similar position, so an electric atmosphere is expected at the City of Cardiff Stadium, but Ireland goalkeeper Darren Randolph says it will be a night for cool heads.
Chris Coleman (Wales): "We're on unsafe ground if we go in with a game plan of trying to soak the pressure up for 90 minutes".
"We are too good to do that".
"I feel over the last three games with Southampton I didn't really have many chances and on Friday I got three but they just wouldn't go in for me". That's the way it's set up. "You want to stay in the game as long as possible".
Wales and Ireland have shut each other out over their past two clashes.
Republic captain Seamus Coleman had his leg broken by a challenge from Wales defender Neil Taylor in the goalless draw and has not played football since.
The match will be under much scrutiny not only because of the high stakes. Whatever game plan we have we will utilise it the best we can. "We were all absolutely devastated at what happened".
Bale's goals fired Wales to last summer's European Championships, a first major tournament since the 1958 World Cup.
Republic of Ireland team is boosted by the return of players Robbie Brady and James McClean who were in the suspension but Shane Long is ruled out of the squad due to the injury.
Spain, the 2010 world champions, secured top spot in Group G after they stormed to a 3-0 win over Albania.
1850: Wales have made just one change from Friday night's win in Georgia with Hal Robson-Kanu selected ahead of Sam Vokes as the central forward option. One would not be enough but would still end Ireland's own play-off dream.
An 0-5 start is a real possibility, as they've made a hard trip cross-country to play the also winless New York Giants on Sunday. NY ranks third-to-last in the league with 3.2 yards per carry, and will be without running back Paul Perkins (ribs) today.
In Cairo, an army helicopter dropped hundreds of Egyptian flags on thousands of fans gathered at the city's iconic Tahrir square. Fans honking vehicle horns and waving Egypt's red, white and black flags took the streets across the country.
The Firm conducts the activities through two distinct and separate businesses: Healthcare and Industrial business units. The Bridges Investment Counsel Inc holds 4,498 shares with $998,000 value, up from 1,197 last quarter.
Over the weekend, the Justice League Twitter announced there would be a trailer that debuts on Sunday, Oct. 8 at 9:00 a.m. That's a bit more inspirational than the hard-driving "Come Together" cover in the previous trailer .
But on Sunday, a sea of Spanish flags, interspersed with some Catalan and European Union flags, dominated Barcelona's boulevards. At the same time, according to Rahoy, the Spanish authorities do not need any mediation to settle the situation in Catalonia.
Understand, the Justice Department under Sessions is already reversing numerous positions it held under President Barack Obama. However, portions of the memo seem to set things up for people to use religious freedom as a basis for LGBTI discrimination.
Scott Gottlieb said in a statement that the agency is working to prevent shortages of about 40 crucial medicines. One by one, cars are pulling into the parking lot filled with food and supplies for the people of Puerto Rico .
For some reason, with just two games behind each team, a consensus had been formed that Miami was good and Florida State was not. On the ensuing possession, he converted a third-and-10 before being intercepted by Stanford Samuels III two plays later.
Striker Richmond Boakye-Yiadom struck powerfully from 20 yards out and his effort came off the chin of goalkeeper Denis Onyango. Many Ghanaians have expressed regret over the quality of officiating with many asking for a replay of the game.
In Europe, Cristiano Ronaldo scored and helped Portugal win an eighth straight game - althought it still could fail to qualify. One of those three teams will face either Syria or Australia for a place in the World Cup.
Storm surge threatened low-lying communities in southeast Louisiana, eastward to the Alabama fishing village of Bayou la Batre. According to the Associated Press , Nate has been responsible for 22 deaths in Central America, mainly due to flooding.
A petition was created addressed to Akufo-Addo, demanding better regulation and inspection of existing and proposed facilities. A witness said the fire began at a station that sells liquefied natural gas and spread to a petrol station across the street.
Vegas Shooter Booked Hotel Rooms Overlooking Lollapalooza
That said, a senior law enforcement official said that hotels in the vicinity typically have an obstructed view, if one at all. Investigators are still trying to determine a motive for the Las Vegas shooting and Paddock's whereabouts the last few months.
What USMNT needs to do to directly qualify for the World Cup
Pulisic fed an open Altidore for a good opportunity in the third minute, Arriola shot wide in the fourth and Wood in the fifth. However, a win by Panama and a Honduras loss to Costa Rica would ensure a place for Los Canaleros in Russian Federation .
School guard burns four toddlers to death in Brazil
Hospitals nearby were overwhelmed by the attack, and five surrounding cities have sent emergency services to aid in the rescue. At least 40 other people have been injured in the fire, according to reports.